Bioactive toothpastes for dentine hypersensitivity

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The prevalence of dentin hypersensitivity is given as 1.3 to 92% (Dentist Elf - 23approx January 2019). Dentin hypersensitivity usually presents as a brief, sharp ache from uncovered dentin because of a thermal, tactile, osmotic chemical or evaporation stimulus that isn't attributable to another dental pathology. A wide range of brokers have been used to deal with hypersensitivity, together with a variety of desensitizing toothpastes. Bioactive toothpastes use a bioactive glass that precipitates calcium and phosphate ions that may block the dentinal tubules.

The intention of this overview was to guage the effectiveness of bioactive glass toothpastes used both at house or within the workplace to deal with dentin hypersensitivity.

Methods

The overview was registered and adopted up with PROSPERO PRISM Guidelines. Research was carried out within the databases Medline / PubMed, CENTRAL, Web of Science and LILACS. This was supplemented by analysis within the ProQuest Dissertations & Theses Database and Clinical trials , the National Research Register, OpenGrey, the World Health Organization's International Clinical Trials Registry Platform, and the Brazilian Clinical Trials Registry . Randomized managed trials (RCTs) by which bioactive toothpastes had been in contrast with placebo or one other desensitizing agent had been thought-about. Two reviewers independently reviewed and chosen research, extracted knowledge, and rated examine high quality utilizing Cochrane's domain-based instrument. Due to the heterogeneity of the examine, a story abstract was offered.

Results

  • 15 research with a complete of 1,099 sufferers had been included
  • 7 research had been rated as low threat of bias, 4 as medium threat and 4 as excessive threat.
  • Studies used biosilicates in concentrations of 1 to 10% and Novamin® (45S5 / Bioglas) in two broad ranges of 5 to fifteen% and a couple of.5 to 7.5%.
  • Follow-up occasions ranged from 1-24 weeks.

Conclusions

The authors concluded: -

Bioactive compounds in low concentrations (2.5 - 7.5%) can be utilized to deal with dentinal hypersensitivity each at house and within the workplace.

Comments

We have blogged via a number of systematic opinions of therapies for dentinal hypersensitivity. (Dental Elf - Blogs about dentin hypersensitivity). A overview of Hu desensitizing toothpastes. from 2018 et al (Dentist Elf - 20NS July 2018) additionally included calcium sodium phosphosilicate (CSPS) toothpastes, together with 6 research, 4 of that are included on this present overview. For CSPS toothpastes, Hu. carried out a meta-analysis et al they usually discovered that each one toothpastes with desensitizing brokers improved hypersensitivity. This overview included extra research than the earlier overview, however there have been important variations within the size of follow-up and the focus of bioactive materials. While the reviewers rated solely 4 research with a excessive threat of bias, not less than one area with a excessive threat of bias was assessed in 8 of the 15 research. The wide selection of research and their restricted high quality imply that the outcomes have to be considered very rigorously. In basic, dentinal hypersensitivity opinions have proven an absence of top quality research and future research will have to be performed accordingly GHOST and WIFE Guidelines and have widespread follow-up durations and consequence requirements (COMET initiative).

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Primary paper

Freitas SAA, Oliveira NMA, de Geus JL, Souza SFC, Pereira AFV, Bauer J. Bioactive Toothpastes in the Treatment of Dentin Hypersensitivity: A Systematic Review. Saudi Dent J. 2021 Nov; 33 (7): 395-403. doi: 10.1016 / j.sdentj.2021.04.004. Epub 2021 April twenty seventh. PMID: 34803279; PMCID: PMC8589619.

Protocol on PROSPERO. check

different references

Dentist Elf - 23approx January 2019

Dentin Hypersensitivity: How Common is it?

Dentist Elf - 24NS September 2019

Dentin Hypersensitivity: Which Active Ingredients Are Most Effective?

Dentist Elf - 20NS July 2018

Dentin hypersensitivity: effectiveness of desensitizing toothpastes

Dental Elf - Blogs about dentin hypersensitivity


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